Spraguedawley rats have been extensively used for the examination of fructoseinduced hypertension. Cyp2j3 gene delivery reduces insulin resistance via. Therapeutic effects of tender coconut water on oxidative. Fructoseinduced cognitive dysfunction is associated with. The average plasma fructose concentration in the fructosefed mice was 1550. Glut5 is also expressed in skeletal muscle, testis, kidney, fat tissue adipocytes, and brain. Cyp2j3 gene delivery reduces insulin resistance via upregulation of enos in fructosetreated rats.
Jan 01, 2002 although the exact mechanisms by which larginine prevents fructose induced hypertension and hyperinsulinemia in rats remain to be defined, these effects might be the indirect consequences of its vasodilator effect and, hence, an increased blood flow to insulin sensitive tissues. Fructose feeding can also cause insulin resistance and hyperinsulinemia in normal r a t s. If fructose stimulates salt absorption in the intestine and kidney, then it is reasonable to ask whether varying the amount of dietary salt has any impact on fructose induced hypertension. Longterm dietinduced hypertension in rats is associated. The role of salt in the pathogenesis of fructoseinduced. The rats were divided into 4 groups of six each and fed the following diet. Cinnamaldehyde and allopurinol reduce fructoseinduced. Feeding a highfructose diet induces hypertension and insulinresistance in. The results demonstrate that fructoseinduced hyperinsulinemia and impaired glucose tolerance depend on calcium status. Read role of aldehydes in fructose induced hypertension, molecular and cellular biochemistry on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. We investigated whether fructoseinduced leptin resistance in mice could be used to study the metabolic consequences of fructose consumption in humans, particularly in children and adolescents. Chapter 8 effect of tender coconut water in high fructose fed. Fructoseinduced hypertension in rats is concentration and duration.
Dietary lipoic acid supplementation prevents fructoseinduced. Protective effect of ficus infectoria plant extract against. In line with earlier work, plasma insulin concentrations and blood glucose levels in response to a glucose load were markedly elevated in calciumreplete rats fed fructose relative to those fed a standard starchandsucrose. Fructoseinduced hypertension has been shown to be attenuated in both glut5 and pat1 knockout mice. Finally, rats fed the highfructose diet throughout development underwent marked. We hypothesized that a 28week diet rich in fat, fructose. Effects of larginine on blood pressure and metabolic. At this stage, the mechanisms underlying fructose induced hypertension have not been fully characterized and the bulk of our knowledge is derived from animal models. Jun 19, 2018 wistar rat dams were divided into control and fructose fed groups that received 10% fructose in their drinking water from 8 weeks of age and throughout pregnancy 10 weeks. The objective of this study was to evaluate the metabolic aspects and the response to acute physical exercise in rats recovered from fetal protein malnutrition with a fructoserich diet. Masoprocol lowers blood pressure in rats with fructose. Increased body weight was observed in rats receiving high fructose diet, while treatment with metformin prevented the gain of body weight table 1. Studies in rats have confirmed this speculation by showing that high salt intake enhances and low salt intake blunts the magnitude of fructoseinduced. In conclusion, taurine may ameliorate fructose induced hypertension in rats by preventing an increase in intracellular free calcium concentration.
Group 1 control rats group 2 high fructose fed hypertensive rats. A highfructose diet induces insulin resistance but not. Beneficial effects of zingiber officinale roscoe on fructose. Frontiers high fructose intake during pregnancy in rats. Inulin supplementation prevents high fructose dietinduced. Pregnant wistar rats were fed with a balanced b diet or a lowprotein l diet.
Calcitriol ameliorated systolic hypertension in the fructosefed rats changes in sbp in the fructosefed rats with or without calcitriol treatment are shown in fig. Increased sugar consumption, especially fructose, is strongly related to the development of type 2 diabetes t2d and metabolic syndrome. In parallel studies, a chloridefree diet blocked fructose induced hypertension in sprague dawley rats. The correlation between fructoseinduced hypertension and hyperinsulinemia was also evaluated. Although the exact mechanisms by which larginine prevents fructoseinduced hypertension and hyperinsulinemia in rats remain to be defined, these effects might be the indirect consequences of its vasodilator effect and, hence, an increased blood flow to insulin sensitive tissues. Wistar rat dams were divided into control and fructose fed groups that received 10% fructose in their drinking water from 8 weeks of age and throughout pregnancy 10 weeks. Fructose induced insulin resistance and hypertension in rats ishun hwang, helen ho, brian b. Rats fed a high fructose diet represent an animal model for insulin resistance and hypertension.
Pdf aqueous extract of monascus purpureus m9011 prevents. After induction of diabetes, rats were divided into four groups for the oral ingestion of ni, nisln andor vehicles and their effects on blood glucose levels, oral glucose toler. In addition, hyperinsulinemia and hypertriglyceridemia were associated with hypertension in fructosefed rats. Animals male sprague dawley rats weighing between 150170 g were used for the study. Dietary lipoic acid supplementation prevents fructose. Studies in rats have confirmed this speculation by showing that high salt intake enhances and low salt intake blunts the magnitude of fructose induced. Glut5 allows for fructose to be transported from the intestinal lumen into the enterocyte by facilitated diffusion due to fructoses high concentration in the intestinal lumen. Mangiferin diminishes chronic fructose overconsumption induced cardiac fibrosis in spontaneous hypertension rats ling yao 1, chunli li2, ting chen1, weiguo cao, johji yamahara3, yuhao li1,4, yunmei zhang5, jianwei wang1 1chongqing key laboratory of traditional chinese medicine for prevention and cure of metabolic diseases. Highfructose diet during periadolescent development. Fructose reduces the production of nitric oxide and makes it difficult for the vessels to relax and dilate. Fructose also raises uric acid in the blood, she says, and that could raise blood pressure. Dec 11, 2014 indeed, several studies have pointed to the adverse cardiac and metabolic effects of a high fructose diet in animal models. Aboubakar1, leonard tedong2, pierre kamtchouing1 and theophile dimo1 abstract background.
Fructoseinduced hypertension in rats is concentration. These data suggest that fructose alone does not induce hyperinsulinemia or hypertension in rats fed a normal rna. Beneficial effects of zingiber officinale roscoe on. Pdf the effect of losartan and carvedilol on renal. Fructoseinduced hypertension has been shown to be attenuated in both glut5 and pat1 knockout mice 21,22. Antihypertensive treatment with enrasentan sb217242 in. We recently showed that a high fructose diet containing vegetable oil but a normal sodiumpotassium ratio induced mild insulin resistance with decreased insulin receptor substrate1 tyrosine phosphorylation in the liver and muscle of normal rats. Highfructose diet during periadolescent development increases depressivelike behavior and remodels the hypothalamic. The addition of clonidine to the drinking water inhibited fructoseinduced hypertension, but not the increase in plasma insulin or triglyceride concentration seen in fructosefed rats. Oct 30, 2009 fructose reduces the production of nitric oxide and makes it difficult for the vessels to relax and dilate. A highfructose diet induces insulin resistance but not blood. The most salient feature of the present studies is the prevention of generation of fructoseinduced hypertension in mice lacking slc26a6 and in rats on a chloridefree diet figures 4 and 5, clearly establishing the role of dietary chloride and chlorideabsorbing transporter slc26a6 in the pathogenesis of fructoseinduced hypertension. Role of aldehydes in fructose induced hypertension, molecular.
Metabolic syndrome and hypertension resulting from. The tissue reninangiotensin system in rats with fructoseinduced hypertension. Hyperlipidemia and hypoglycemia in rats were induced by fructose. Metabolic syndrome signs in wistar rats submitted to. The relation between fructoseinduced metabolic syndrome and. The present study determined the most suitable concentration and duration of fructose treatment for inducing hypertension in wistar rats. High fructose consumption is a risk factor for diabetes. Cardiovascular effects of highfructose intake in rats.
Fructoseinduced hypertension in rats is concentration and durationdependent. Oral taurine supplementation prevents fructoseinduced. Indeed, several studies have pointed to the adverse cardiac and metabolic effects of a high fructose diet in animal models. Dietary fructose and hypertension, current hypertension. Sep 11, 2014 high fructose diets have been implicated in obesity via impairment of leptin signaling in humans and rodents. Activated pathogenic th17 lymphocytes induce hypertension. Three months of highfructose feeding fails to induce.
Overexpression of type 1 angiotensin ii receptor in adipose tissue. The effect of losartan and carvedilol on renal haemodynamics and altered metabolism in fructosefed spraguedawley rats. Beneficial effects of calcitriol on hypertension, glucose. Amplified vasopressor responses to minimal stimuli and differing responses to fructose in peripheral versus central sites may explain the controversy. Attenuation of fructoseinduced hypertension in rats by exercise training, 12. Type 2 diabetes is associated with cognitive and memory impairment. Prevention of fructoseinduced hypertension by dietary.
Bidens pilosa ethylene acetate extract can protect against. Essential hypertension is mainly caused by endothelial dysfunction. Diabetes was induced into rats by the administration of fructose 10% in drinking water for six weeks. Excess maternal salt or fructose intake programmes sexspecific, stress and fructose sensitive hypertension in the offspring volume 115 issue 4 clint gray, sheila m. Glut5 allows for fructose to be transported from the intestinal lumen into the enterocyte by facilitated diffusion due to fructose s high concentration in the intestinal lumen. All intext references underlined in blue are added to the original document and are linked to publications on researchgate, letting you access and read them. We recently showed that a highfructose diet containing vegetable oil but a normal sodiumpotassium ratio induced mild insulin resistance with decreased insulin receptor substrate1 tyrosine phosphorylation in the liver and muscle of normal rats. Rats given a diet high in fructose have elevated fasting insulin and glucose, elevated insulin response to oral glucose load, significantly elevated triglycerides and elevated blood pressure. Excess maternal salt or fructose intake programmes sex. Oct 15, 2004 read role of aldehydes in fructose induced hypertension, molecular and cellular biochemistry on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Highfructose diets have been implicated in obesity via impairment of leptin signaling in humans and rodents. An increase in adenosine5triphosphate atp content in. Metabolic responses to acute physical exercise in young. Oct 19, 2010 the association between fructose and increased blood pressure is still incompletely defined, because experimental studies have produced dissimilar conclusions.
Metabolic syndrome and hypertension resulting from fructose. A highfructose diet caused a significant rise in sbp from the baseline value of 118 4. Therapeutic effects of tender coconut water on oxidative stress in. The user has requested enhancement of the downloaded file. Excess maternal salt or fructose intake programmes sexspecific, stress and fructosesensitive hypertension in the offspring volume 115 issue 4 clint gray, sheila m. Pdf fructoseinduced hypertension in rats is concentration and. The addition of clonidine to the drinking water inhibited fructose induced hypertension, but not the increase in plasma insulin or triglyceride concentration seen in fructose fed rats. We investigated whether fructose induced leptin resistance in mice could be used to study the metabolic consequences of fructose consumption in humans, particularly in children and adolescents. Pdf fructoseinduced insulin resistance and hypertension. In conclusion, taurine may ameliorate fructoseinduced hypertension in rats by preventing an increase in intracellular free calcium concentration. Pdf the present study determined the most suitable concentration and duration of fructose treatment for inducing hypertension in wistar rats. Glut5 is a fructose transporter expressed on the apical border of enterocytes in the small intestine. Previous studies performed in animals have demonstrated the antihypertensive efficacy of etreceptor antagonists in doca salt rats, in dahlss rats, in hypertension induced by angiotensin ii infusion, and in rats with a highfructose diet, whereas these drugs were unable to lower blood pressure in shr and in renovascular models of. However, evidence has been published that inhibitors of 12lipoxygenase activity can lower blood pressure in spontaneously hypertensive rats, as well as in rats with renovascular hypertension.
The tissue reninangiotensin system in rats with fructose. In contrast, mangiferin attenuated fructoseinduced acceleration of plasma nefa clearance during ogtt, and tended to decrease excessive triglyceride accumulation in gastrocnemius. Preparation and antidiabetic effect of orally administered. Bidens pilosa ethylene acetate extract can protect against l. In parallel studies, a chloridefree diet blocked fructoseinduced hypertension in sprague dawley rats. Animal studies have shown that high fructose diets upregulate sodium and chloride transporters, resulting in a state of salt overload that increases blood. Relative liver weight and plasma concentrations of glucose and triglycerides. The association between fructose and increased blood pressure is still incompletely defined, because experimental studies have produced dissimilar conclusions. Dietary lipoic acid supplementation prevents fructoseinduced hypertension in rats article in nutrition metabolism and cardiovascular diseases 106. Fructoseinduced insulin resistance and hypertension in rats.
Furthermore, clonidine blocks the hypertension, but not the metabolic effects of fructose. Fructose drinking rats had increased blood pressure and impaired acetylcholine induced relaxation of the thoracic aorta in comparison with control rats drinking just tap water. Fructoseinduced insulin resistance and hypertension in rats ishun hwang, helen ho, brian b. Fructose induces systemic hypertension through several mechanisms mainly associated. The effects of metformin on metabolic changes in insulin resistant rats. College of pharmacy, navarangpura, ahmedabad 380 009, india received 8 september 2004. Protective effect of ficus infectoria plant extract. If fructose stimulates salt absorption in the intestine and kidney, then it is reasonable to ask whether varying the amount of dietary salt has any impact on fructoseinduced hypertension. Relative liver weight and plasma concentrations of glucose and triglycerides were also elevated after fructose administration.
In wistar rats, 21 weeks of fructose supplementation induced a metabolic syndrome hypertension, insulin resistance, and dyslipidemia but not t2d. Chapter 8 effect of tender coconut water in high fructose. The blood pressurelowering effect of taurine appeared to be independent from its effect on glucose and lipid metabolism in this model. Nov 04, 2009 hypertension is the most common chronic disease in developed countries. The rats were treated with 5%, 10%, or 20% fructose in drinking water. Fructosefed rats and mice show moderate hypertension and glucose intolerance, associated with increased levels of plasma insulin, cholesterol and triglycerides 35. Fructose feeding decreased salt excretion by the kidney and resulted in hypertension, a response almost abolished in the knockout mice. Serum uric acid remained unchanged in animals on increased fructose intake with hypertension. Cardiovascular autonomic dysfunction and oxidative stress. Aqueous extract of monascus purpureus m9011 prevents and reverses fructose induced hypertension in rats. Male c57bl6 mice were weaned to a randomly assigned diet.
Materials and methods general protocol male spraguedawley rats simonsen laboratories, gilroy, ca, usa, initially weighing 160 to 180 g. Histology of heart sections in different groups was examined by oil red o. Cellular mechanisms of insulin resistance in rats with fructose. Cardiovascular effects of highfructose intake in rats with. The effect of various interventions on fructoseinduced hypertension and insulin resistance in rat. Pdf dietary vitamin e and c supplementation prevents. In normotensive rats fed with high fructose diet hfd for 12 weeks, there was a significant increase in tissue atp content in rvlm, accompanied by. Original article mangiferin diminishes chronic fructose. We examined in this study whether fructose affects atp content in rvlm and its significance in the increase in central sympathetic outflow and hypertension induced by the high fructose diet hfd. Fructose, insulin resistance, and metabolic dyslipidemia. Effects of lnmma on fructoseinduced hypertension with cyp2j3 gene delivery in rats. Fructose induces systemic hypertension through several mechanisms mainly. Effects of larginine on blood pressure and metabolic changes. Masoprocol lowers blood pressure in rats with fructoseinduced.
Role of aldehydes in fructose induced hypertension. The metabolic changes determined at 4 weeks after balloon injury and following 4week high fructose diet are summarized in table 1. Pdf role of aldehydes in fructose induced hypertension. Mangiferin diminishes chronic fructose overconsumptioninduced cardiac fibrosis in spontaneous hypertension rats ling yao 1, chunli li2, ting chen1, weiguo cao, johji yamahara3, yuhao li1,4, yunmei zhang5, jianwei wang1 1chongqing key laboratory of traditional chinese medicine for prevention and cure of metabolic diseases. High fructose intake induced hypertension via the activation of pathogenic th17 lymphocytes in ss but not sr rats. Aug 02, 2008 the most salient feature of the present studies is the prevention of generation of fructose induced hypertension in mice lacking slc26a6 and in rats on a chloridefree diet figures 4 and 5, clearly establishing the role of dietary chloride and chlorideabsorbing transporter slc26a6 in the pathogenesis of fructose induced hypertension. Sucrose or fructoseinduced hypertension evidence for sucrose or fructoseinduced hypertension in animal models. Rats fed a highfructose diet represent an animal model for insulin resistance and hypertension. Dec 21, 2011 effects of cyp2j3 gene delivery on cyp2j3 protein expression, plasma and urinary 14,15dhet levels. Injection of activated th17 lymphocytes isolated from fructose fed ss rats induced hypertension via increase of serum il17a in only recipient ss rat. Histology of heart sections in different groups was examined by oil red o a and masson trichrome. To determine if fructose intake might affect memory function independently of diabetes development, we investigated the effects of monosaccharides on memory in prediabetic state. Sucrose or fructose induced hypertension evidence for sucrose or fructose induced hypertension in animal models. Cinnamaldehyde and allopurinol reduce fructose induced cardiac hypertrophy and fibrosis in rats.
Fructoseinduced hypertension in rats is concentration and. Mitigation of insulin resistance by mangiferin in a rat. Rats with fructoseinduced hypertension were treated by oral gavage with either. Fructosefed rats and mice show moderate hypertension and glucose intolerance, associated with increased levels of. Reaven summary to determine if hypertension could be produced in normal rats by feeding them a. Maternal fecal and blood samples were collected premating 9 weeks and during early gestational day 47 and late pregnancy gestational day 1921. Increased fructose associates with elevated blood pressure. Regarding liver antioxidant status, oxidative stress was observed in fructose fed rats fgroup, while. The mechanisms underlying fructoseinduced hypertension. High fructose intake may raise blood pressure webmd. Mechanistically, mangiferin neither affected intakes of fructose and chow, and the increase in epididymal and perirenal fat, nor attenuated fructoseinduced hypertension. Abdominal obesity andor a high intake of fructose may cause hypertension. Cinnamaldehyde and allopurinol reduce fructoseinduced cardiac hypertrophy and fibrosis in rats.
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